Clinicl Studies Directory
Preventive treatment (episodic and chronic migraine)
Temporal patterns of response to treatment (coming soon)
Health economics analysis (coming soon)
Acute treatment of episodic migraine
Adolescents with migraine
Chronic migraine
Comparison of Nerivio and medications
Real-world studies
In-app behavioral intervention
Menstrual migraine
Independent scientific support
The evidence regarding the efficacy and safety of Nerivio have been examined by several impartial scientific reviews and meta-analysis.
Systematic meta-analysis review of neuromodulation devices for migraine Moisset et al, 2020 10
The only neurostimulation device with sufficient evidence-based research supporting efficacy for acute migraine treatment.
Moisset X, Pereira B, Ciampi de Andrade D, Fontaine D, Lantéri-Minet M, Mawet J. Neuromodulation techniques for acute and preventive migraine treatment: a systematic review and meta-analysis of randomized controlled trials. J Headache Pain. 2020;21(1):142. doi:10.1186/s10194-020-01204-4
Systematic Review and Meta-analysis of Acute Treatments for Episodic Migraine in Adults VanderPluym et al., June 2021, JAMA 11
The only neurostimulation device with moderate strength of evidence (SOE).
VanderPluym JH, Halker Singh RB, Urtecho M, et al. Acute Treatments for Episodic Migraine in Adults: A Systematic Review and Meta-analysis. JAMA. 2021;325(23):2357-2369. doi:10.1001/jama.2021.7939
Latest guidelines of the French Headache Society for treating migraine Demarquay et al., July 202112
The only neurostimulation device with moderate strength of evidence (SOE) by the French Headache Society.
Demarquay G, Mawet J, Guégan-Massardier E, et al. Revised guidelines of the French headache society for the diagnosis and management of migraine in adults. Part 3: Non-pharmacological treatment. Rev Neurol (Paris). 2021;177(7):753-759. doi:10.1016/j.neurol.2021.07.009
Nerivio’s scientific reviews
Bibliography
Bibliography
1. Rapoport AM, Bonner JH, Lin T, et al. Remote electrical neuromodulation (REN) in the acute treatment of migraine: a comparison with usual care and acute migraine medications. J Headache Pain. 2019;20(1):83.
2. Grosberg B, Rabany L, Vizel M, et al. Effectiveness comparison of remote electrical neuromodulation and standard-care medications for acute treatment of chronic migraine: a post-hoc analysis. Pain Manag. Published online September 13, 2022. doi:10.2217/pmt-2022-0053
3. Hershey AD, Irwin S, Rabany L, et al. Comparison of remote electrical neuromodulation (REN) and standard-care medications for acute treatment of migraine in adolescents: a post-hoc analysis. Pain Med. 2021;(pnab197). doi:10.1093/pm/pnab197
4. Marmura MJ, Lin T, Harris D, Ironi A, Rosen NL. Incorporating Remote Electrical Neuromodulation (REN) Into Usual Care Reduces Acute Migraine Medication Use: An Open-Label Extension Study. Front Neurol. 2020;11. doi:10.3389/fneur.2020.00226
5. Ailani J, Rabany L, Tamir S, Ironi A, Starling A. Real-World Analysis of Remote Electrical Neuromodulation (REN) for the Acute Treatment of Migraine. Front Pain Res. 2022;2. Accessed February 8, 2022. https://www.frontiersin.org/article/10.3389/fpain.2021.753736
6. Esparham A, Stark-Inbar A, Jekel L, et al. Acute Treatment of Migraine in Adolescents: Real-World Analysis of Remote Electrical Neuromodulation (REN). Pediatr Neurol. Published online 2023.
7. Tepper SJ, Lin T, Montal T, Ironi A, Dougherty C. Real-world Experience with Remote Electrical Neuromodulation in the Acute Treatment of Migraine. Pain Med. doi:10.1093/pm/pnaa299
8. Buse DC, Rabany L, Lin T, Ironi A, Connelly MA, Bickel JL. Combining Guided Intervention of Education and Relaxation (GIER) with Remote Electrical Neuromodulation (REN) in the Acute Treatment of Migraine. Pain Med Malden Mass. Published online February 11, 2022:pnac021. doi:10.1093/pm/pnac021
9. Nierenburg H, Rabany L, Lin T, et al. Remote Electrical Neuromodulation (REN) for the Acute Treatment of Menstrual Migraine: a Retrospective Survey Study of Effectiveness and Tolerability. Pain Ther. Published online June 17, 2021. doi:10.1007/s40122-021-00276-7
10. Moisset X, Pereira B, Ciampi de Andrade D, Fontaine D, Lantéri-Minet M, Mawet J. Neuromodulation techniques for acute and preventive migraine treatment: a systematic review and meta-analysis of randomized controlled trials. J Headache Pain. 2020;21(1):142. doi:10.1186/s10194-020-01204-4
11. VanderPluym JH, Halker Singh RB, Urtecho M, et al. Acute Treatments for Episodic Migraine in Adults: A Systematic Review and Meta-analysis. JAMA. 2021;325(23):2357-2369. doi:10.1001/jama.2021.7939
12. Demarquay G, Mawet J, Guégan-Massardier E, et al. Revised guidelines of the French headache society for the diagnosis and management of migraine in adults. Part 3: Non-pharmacological treatment. Rev Neurol (Paris). 2021;177(7):753-759. doi:10.1016/j.neurol.2021.07.009
13. McVige JW, Stark-Inbar A. Remote Electrical Neuromodulation for the Acute Treatment of Episodic and Chronic Migraine. Published online August 2, 2021. Accessed August 5, 2021. https://touchneurology.com/headache/journal-articles/remote-electrical-neuromodulation-for-the-acute-treatment-of-episodic-and-chronic-migraine/
14. Nierenburg H, Stark-Inbar A. Nerivio® remote electrical neuromodulation for acute treatment of chronic migraine. Pain Manag. Published online September 20, 2021. doi:10.2217/pmt-2021-0038
15. Rapoport AM, Lin T. Device profile of the NerivioTM for acute migraine treatment: overview of its efficacy and safety. Expert Rev Med Devices. 2019;0(0):1-7. doi:10.1080/17434440.2019.1695599
